Mammalian erythropoiesis is the process by which blood stem cells differentiate into red blood cells. It is an accessible experimental system that allows us to address fundamental questions in biology and disease.
Erythropoietic deficits are common worldwide, manifesting as anemia or malignant conditions such as myelodysplasia or myeloproliferative disease.
We investigate how cell fate decisions during erythropoiesis are orchestrated by DNA replication and by epigenetic mechanisms. We also study the systems biology principles that allow a massive ramping up of red cell production in response to the stress of bleeding, anemia or hypoxia.
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