Publications

Follow this link for the up-to-date list of publications on Pubmed.

(57) Jouravleva K, Golovenko D, Demo G, Dutcher RC, Hall TM, Zamore PD, Korostelev AA. Structural Basis of MicroRNA Biogenesis by Dicer-1 and Its Partner Protein Loqs-PB. bioRxiv. 2022.

(56) Loveland AB, Svidritskiy E, Susorov D, Lee S, Park A, Demo G, Gao FB, Korostelev AA. Ribosome inhibition by C9ORF72-ALS/FTD-associated poly-PR and poly-GR proteins revealed by cryo-EM. Nat. Commun. 2022. 13: 2776.

(55) Korostelev AA. The Structural Dynamics of Translation. Annual Reviews of Biochemistry. Review. 2022. 91.

(54) Carbone CE, Loveland AB, Gamper HB Jr, Hou YM, Demo G, Korostelev AA. Time-resolved cryo-EM visualizes ribosomal translocation with EF-G and GTP. Nat. Commun. 2021. 12(1):7236. 

(53) Korostelev AA. Diversity and Similarity of Termination and Ribosome Rescue in Bacterial, Mitochondrial, and Cytoplasmic Translation. Biochemistry (Mosc). Review. 2021. 86(9):1107-1121

(52) Demo G, Loveland AB, Svidritskiy E, Gamper HB, Hou Y-M, Korostelev AA. Structural basis for +1 ribosomal frameshifting during EF-G-catalyzed translocation. Nat. Commun. 2021. 12(1):4644.

(51) Carbone CE, Demo G, Madireddy R, Svidritskiy E, Korostelev AA. ArfB can displace mRNA to rescue stalled ribosomes. Nat. Commun. 2020. 11(1): 5552.

(50) Susorov D, Egri S, Korostelev AA. Termi-Luc: a versatile assay to monitor full-protein release from ribosomes. RNA. 2020. 26: 2044–2050.

(49) Loveland AB, Demo G, Korostelev AA. Cryo-EM of elongating ribosome with EF-Tu elucidates tRNA proofreading. Nature. 2020. 584: 640–645.

(48) Hsu HL, Brown A, Loveland AB, Lotun A, Xu M, Luo L, Xu G, Li J, Ren L, Su Q, Gessler DJ, Wei Y, Tai PWL, Korostelev AA, Gao G. Structural Characterization of a Novel Human Adeno-Associated Virus Capsid with Neurotropic Properties.  Nat. Commun. 2020. 11: 3279.

(47) Huang S, Aleksashin N, Loveland AB, Klepacki D, Reier K, Kefi A, Szal T, Remme J, Jaeger L, Vázquez-Laslop N, Korostelev AA, Mankin A. Ribosome engineering reveals the importance of 5S rRNA autonomy for ribosome assembly.  Nat. Commun. 2020. 11: 2900.

(46) Bao C, Loerch S, Ling C, Korostelev AA, Grigorieff N, Ermolenko DN. mRNA Stem-loops Can Pause the Ribosome by Hindering A-site tRNA Binding. eLife. 2020. 9: e55799.

(45) Svidritskiy E, Demo G, Loveland AB, Xu C, Korostelev AA. Extensive ribosome and RF2 rearrangements during translation termination. eLife. 2019 Sep 12;8. pii: e46850.

(44) Ulirsch JC, Verboon JM, Kazerounian S, Guo MH, Yuan D, Ludwig LS, Handsaker RE, Abdulhay NJ, Fiorini C, Genovese G, Lim ET, Cheng A, Cummings BB, Chao KR, Beggs AH, Genetti CA, Sieff CA, Newburger PE, Niewiadomska E, Matysiak M, Vlachos A, Lipton JM, Atsidaftos E, Glader B, Narla A, Gleizes PE, O'Donohue MF, Montel-Lehry N, Amor DJ, McCarroll SA, O'Donnell-Luria AH, Gupta N, Gabriel SB, MacArthur DG, Lander ES, Lek M, Da Costa L, Nathan DG, Korostelev AA, Do R, Sankaran VG, Gazda HT. The Genetic Landscape of Diamond-Blackfan Anemia. Am J Hum Genet. 2018. 103(6):930-947.

(43) Svidritskiy E, Demo G, Korostelev AA. Mechanism of premature translation termination on a sense codon. J Biol Chem. 2018. 293(32):12472-12479.

(42) Svidritskiy E, Korostelev AA. Conformational Control of Translation Termination on the 70S Ribosome. Structure. 2018. 26(6):821-828.

(41) Svidritskiy E, Korostelev AA. Mechanism of Inhibition of Translation Termination by Blasticidin S. J Mol Biol. 2018. 430(5):591-593. 

(40) Loveland AB, Korostelev AA. Structural dynamics of protein S1 on the 70S ribosome visualized by ensemble cryo-EM. Methods. 2018. 137:55-66. 

(39) Demo G, Rasouly A, Vasilyev N, Svetlov V, Loveland AB, Diaz-Avalos R, Grigorieff N, Nudler E, Korostelev AA. Structure of RNA polymerase bound to ribosomal 30S subunit. eLife. 2017 Oct 13;6. e28560.

(38) Loveland AB, Demo G, Grigorieff N, Korostelev AA. Ensemble cryo-EM elucidates the mechanism of translation fidelity. Nature. 2017. 546(7656):113-117. (animation)

(37) Koh CS, Madireddy R, Beane TJ, Zamore PD, Korostelev AA. Small methyltransferase RlmH assembles a composite active site to methylate a ribosomal pseudouridine. Scientific Reports. 2017. Apr 20;7(1):969.

(36) Demo G, Svidritskiy E, Madireddy R, Diaz-Avalos R, Grant T, Grigorieff N, Sousa D, Korostelev AA. Mechanism of ribosome rescue by ArfA and RF2. eLife. 2017 Mar 16;6. eLife.23687. (animation)

(35) Loveland AB, Bah E, Madireddy R, Zhang Y, Brilot AF, Grigorieff N, Korostelev AA. Ribosome•RelA structures reveal the mechanism of stringent response activation. eLife. 2016 July 19. (animation)

(34) Abeyrathne PD, Koh CS, Grant T, Grigorieff N, Korostelev AA. Ensemble cryo-EM uncovers inchworm-like translocation of a viral IRES through the ribosome. eLife. 2016 May 9. (animation)

(33) Svidritskiy E, Madireddy R, Korostelev AA. Structural Basis for Translation Termination on a Pseudouridylated Stop Codon. J Mol Biol. 2016 Apr 20.

(32) Tek A, Korostelev AA, Flores SC. MMB-GUI: a fast morphing method demonstrates a possible ribosomal tRNA translocation trajectory. Nucleic Acids Res. 2016 Jan 8;44(1):95-105.

(31) Svidritskiy E, Korostelev AA. Ribosome Structure Reveals Preservation of Active Sites in the Presence of a P-Site Wobble Mismatch. Structure. 2015 Nov 3;23(11):2155-61.

(30) Colussi TM, Costantino DA, Zhu J, Donohue JP, Korostelev AA, Jaafar ZA, Plank TD, Noller HF, Kieft JS. Initiation of translation in bacteria by a structured eukaryotic IRES RNA. Nature. 2015. 5;519(7541):110-3.

(29) Korostelev AA. A Deeper Look into Translation Initiation. Cell. 2014. 3: 475–6. doi: 10.1016/j.cell.2014.10.005. PMID: 25417100.

(28) Svidritskiy E, Brilot AF, Koh CS, Grigorieff N, Korostelev AA. Structures of Yeast 80S Ribosome-tRNA Complexes in the Rotated and Nonrotated Conformations. Structure 2014 Aug 5;22(8):1210-8. doi: 10.1016/j.str.2014.06.003. PMID: 25043550.

(27) Koh CS, Brilot AF, Grigorieff N, Korostelev AA. Taura syndrome virus IRES initiates translation by binding its tRNA-mRNA-like structural element in the ribosomal decoding center. Proc Natl Acad Sci U S A. 2014. 111(25):9139–9144. doi: 10.1073/pnas.1406335111.

(26) Brilot AF, Korostelev AA, Ermolenko DN, Grigorieff N. Structure of the ribosome with elongation factor G trapped in the pretranslocation state. Proc Natl Acad Sci U S A. 2013. 110(52):20994-9. doi: 10.1073/pnas.1311423110. Epub 2013 Dec 9. PMID: 24324137.

(25) Svidritskiy E, Ling C, Ermolenko DN, Korostelev AA. Blasticidin S inhibits translation by trapping deformed tRNA on the ribosome. Proc Natl Acad Sci U S A. 2013. 110(30): 12283–12288. Published online 2013 July 3. doi: 10.1073/pnas.1304922110 PMID: 23824292.

(24) Santos N, Zhu J, Donohue JP, Korostelev AA, Noller HF. Crystal structure of the 70S ribosome bound with the Q253P mutant form of release factor RF2.. Structure 2013 Jul 2;21(7):1258-63. doi: 10.1016/j.str.2013.04.028. Epub 2013 Jun 13. PubMed PMID: 23769667.

(23) Zhou J, Korostelev A, Lancaster L, Noller HF. Crystal structures of 70S ribosomes bound to release factors RF1, RF2 and RF3. Curr Opin Struct Biol. 2012 Dec;22(6):733-42. doi: 10.1016/j.sbi.2012.08.004. Epub 2012 Sep 19. PubMed PMID: 22999888.

(22) Korostelev AA. Structural aspects of translation termination on the ribosome. RNA. 2011 Aug;17(8):1409-21. doi: 10.1261/rna.2733411. Epub 2011 Jun 23. Review. PubMed PMID: 21700725; PubMed Central PMCID: PMC3153966.

(21) Noller HF, Ermolenko DN, Korostelev A, Laurberg M, Zhu, J, Asahara H, Lancaster L, Horan L, Hirschi A, Donohue JP, Trakhanov S, Spiegel C, Hickerson R, Cornish P and Ha T. 2011. “Studies on the mechanisms of translocation and termination”. In: Ribosomes, Structure, Function, and Dynamics. (eds. M.V. Rodnina, W. Wintermeyer and R. Green) Springer, Wien, New York. pp 349-360.

(20) Korennykh AV, Egea PF, Korostelev AA, Finer-Moore J, Stroud RM, Zhang C, Shokat KM, Walter P. Cofactor-mediated conformational control in the bifunctional kinase/RNase Ire1. BMC Biol. 2011 Jul 6;9:48. doi: 10.1186/1741-7007-9-48. PubMed PMID: 21729334; PubMed Central PMCID: PMC3158555.

(19) Korennykh AV, Korostelev AA, Egea PF, Finer-Moore J, Stroud RM, Zhang C, Shokat KM, Walter P. Structural and functional basis for RNA cleavage by Ire1. BMC Biol. 2011 Jul 6;9:47. doi: 10.1186/1741-7007-9-47. PubMed PMID: 21729333; PubMed Central PMCID: PMC3149027.

(18) Zhu J, Korostelev A, Costantino DA, Donohue JP, Noller HF, Kieft JS. Crystal structures of complexes containing domains from two viral internal ribosome entry site (IRES) RNAs bound to the 70S ribosome. Proc Natl Acad Sci U S A. 2011 Feb 1;108(5):1839-44. doi: 10.1073/pnas.1018582108. Epub 2011 Jan 18. PubMed PMID: 21245352; PubMed Central PMCID: PMC3033271.

(17) Korostelev A, Zhu J, Asahara H, Noller HF. Recognition of the amber UAG stop codon by release factor RF1. EMBO J. 2010 Aug 4;29(15):2577-85. doi: 10.1038/emboj.2010.139. Epub 2010 Jun 29. PubMed PMID: 20588254; PubMed Central PMCID: PMC2928684.

(16) Korostelev A, Laurberg M, Noller HF. Multistart simulated annealing refinement of the crystal structure of the 70S ribosome. Proc Natl Acad Sci U S A. 2009 Oct 27;106(43):18195-200. doi: 10.1073/pnas.0909287106. Epub 2009 Oct 12. PubMed PMID: 19822758; PubMed Central PMCID: PMC2775320.

(15) Korennykh AV, Egea PF, Korostelev AA, Finer-Moore J, Zhang C, Shokat KM, Stroud RM, Walter P. The unfolded protein response signals through high-order assembly of Ire1. Nature. 2009 Feb 5;457(7230):687-93. doi: 10.1038/nature07661. Epub 2008 Dec 14. PubMed PMID: 19079236; PubMed Central PMCID: PMC2846394.

(14) Korostelev A, Asahara H, Lancaster L, Laurberg M, Hirschi A, Zhu J, Trakhanov S, Scott WG, Noller HF. Crystal structure of a translation termination complex formed with release factor RF2. Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19684-9. doi: 10.1073/pnas.0810953105. Epub 2008 Dec 8. PubMed PMID: 19064930; PubMed Central PMCID: PMC2604991.

(13) Korostelev A, Ermolenko DN, Noller HF. Structural dynamics of the ribosome. Curr Opin Chem Biol. 2008 Dec;12(6):674-83. doi: 10.1016/j.cbpa.2008.08.037. Epub 2008 Oct 9. Review. PubMed PMID: 18848900.

(12) Laurberg M, Asahara H, Korostelev A, Zhu J, Trakhanov S, Noller HF. Structural basis for translation termination on the 70S ribosome. Nature. 2008 Aug 14;454(7206):852-7. doi: 10.1038/nature07115. Epub 2008 Jul 2. PubMed PMID: 18596689.

(11) Korostelev A, Noller HF. Analysis of structural dynamics in the ribosome by TLS crystallographic refinement. J Mol Biol. 2007 Nov 2;373(4):1058-70. Epub 2007 Aug 29. PubMed PMID: 17897673; PubMed Central PMCID: PMC2713686.

(10) Korostelev A, Trakhanov S, Asahara H, Laurberg M, Lancaster L, Noller HF. Interactions and dynamics of the Shine Dalgarno helix in the 70S ribosome. Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):16840-3. Epub 2007 Oct 16. PubMed PMID: 17940016; PubMed Central PMCID: PMC2040411.

(9) Korostelev A, Noller HF. The ribosome in focus: new structures bring new insights. Trends Biochem Sci. 2007 Sep;32(9):434-41. Epub 2007 Aug 30. Review. PubMed PMID: 17764954.

(8) Korostelev A, Trakhanov S, Laurberg M, Noller HF. Crystal structure of a 70S ribosome-tRNA complex reveals functional interactions and rearrangements. Cell. 2006 Sep 22;126(6):1065-77. Epub 2006 Sep 7. PubMed PMID: 16962654.

(7) Murray S, Nilsson CL, Hare JT, Emmett MR, Korostelev A, Ongley H, Marshall AG, Chapman MS. Characterization of the capsid protein glycosylation of adeno-associated virus type 2 by high-resolution mass spectrometry. J Virol. 2006 Jun;80(12):6171-6. PubMed PMID: 16731956; PubMed Central PMCID: PMC1472596.

(6) Fabiola F, Korostelev A, Chapman MS. Bias in cross-validated free R factors: mitigation of the effects of non-crystallographic symmetry. Acta Crystallogr D Biol Crystallogr. 2006 Mar;62(Pt 3):227-38. Epub 2006 Feb 22. PubMed PMID: 16510969.

(5) Korostelev A, Fenley MO, Chapman MS. Impact of a Poisson-Boltzmann electrostatic restraint on protein structures refined at medium resolution. Acta Crystallogr D Biol Crystallogr. 2004 Oct;60(Pt 10):1786-94. Epub 2004 Sep 23. PubMed PMID: 15388925.

(4) Gao H, Sengupta J, Valle M, Korostelev A, Eswar N, Stagg SM, Van Roey P, Agrawal RK, Harvey SC, Sali A, Chapman MS, Frank J. Study of the structural dynamics of the E coli 70S ribosome using real-space refinement. Cell. 2003 Jun 13;113(6):789-801. PubMed PMID: 12809609.

(3) Lima S, Hildenbrand J, Korostelev A, Hattman S, Li H. Crystal structure of an RNA helix recognized by a zinc-finger protein: an 18-bp duplex at 1.6 A resolution. RNA. 2002 Jul;8(7):924-32. PubMed PMID: 12166647; PubMed Central PMCID: PMC1370309.

(2) Fabiola F, Bertram R, Korostelev A, Chapman MS. An improved hydrogen bond potential: impact on medium resolution protein structures. Protein Sci. 2002 Jun;11(6):1415-23. PubMed PMID: 12021440; PubMed Central PMCID: PMC2373622.

(1) Korostelev A, Bertram R, Chapman MS. Simulated-annealing real-space refinement as a tool in model building. Acta Crystallogr D Biol Crystallogr. 2002 May;58:761-7. Epub 2002 Apr 26. PubMed PMID: 11976486.

Books & Chapters

(2) Korostelev AA. ”Cryogenic Electron Microscopy (Cryo-EM)”. In: Nucleic Acids in Chemistry and Biology: Edition 4. RCS Publishing. 2022.

(1) Noller HF, Ermolenko DN, Korostelev A, Laurberg M, Zhu J, Asahara H, Lancaster L, Horan L, Hirschi A, Donohue JP, Trakhanov S, Spiegel C, Hickerson R, Cornish P, Ha T. “Studies on the mechanisms of translocation and termination”. In: Ribosomes, Structure, Function, and Dynamics. (eds. M.V. Rodnina, W. Wintermeyer and R. Green) Springer, Wien, New York. pp 349-360. 2011.