Structure and mechanism of macromolecular

machines that act on DNA


The Kelch lab is interested in determining how macromolecular machines work, with special emphasis on machines involved in DNA replication and repair.  Understanding how these machines work will not only illuminate the underpinnings of these critically important cellular pathways, but can also lead to new targets for the development of novel cancer therapeutics and antibiotics. 


We use a combination of biochemistry, biophysics and structural methods to elucidate how these vitally important protein complexes are integrated into cellular pathways. 

We are currently seeking a motivated postdoctoral scholar to join us! See description here.


Kelch Lab News