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We are interested in understanding the mechanisms that govern post-transcriptional regulation of gene expression during development and complex disease. Our research is focused primarily in three areas:
1. Post-transcriptional regulatory mechanisms involved in axis polarization and cell fate specification during Caenorhabditis elegans embryogenesis.
2. Characterization of post-transcriptional regulatory mechanisms that guide oligodendrocyte differentiation and myelin formation in the vertebrate central nervous system.
3. Identification of small molecule inhibitors of RNA-binding protein function using high throughput screening approaches.
We employ a combination of biochemical and molecular genetic methods, bioinformatics, chemical biology, biophysics, and structural analsyses in our studies, with a focus on quantitative measurements.
Read more about our research here.
Farley, B.M. and Ryder, S.P. (2012) Mol. Biol. Cell, 23, 4473-4483.
Zearfoss, N.R. and Ryder, S.P. (2012) Methods Mol Biol., 941, 181-193.
Broderick, J.A., Salomon, W., Ryder, S.P., Aronin, N., and Zamore, P.D. (2011) RNA. 17, 1858-1869.
Kalchhaueser, I., Farley, B.M., Pauli, S., Ryder, S.P., and Ciosk, R, (2011) EMBO J. 30, 3823-3829.
Wright, J.E., Gaidatzis, D., Senften, M., Farley, B.M., Westhof, E., Ryder, S.P., Ciosk, R. (2011) EMBO J. 30, 533-545.
Zearfoss, N.R., Clingman, C.C., Farley, B.M., McCoig, L.M., and Ryder, S.P. (2011) PLoS Genet, 7, e1001269. doi:10.1371/journal.pgen.1001269
Pagano, J.M. Clingman, C.C., and Ryder, S.P. (2011) RNA, 17, 14-20.
Campus Address: Lazare Research Building, 9th floor, Office 906
Sean P. Ryder, Ph.D.
Associate Professor
Department of Biochemistry and Molecular Pharmacology
University of Massachusetts Medical School
Joined the faculty in August of 2005.
