We are interested in understanding the mechanisms that govern post-transcriptional regulation of gene expression during development and complex disease. Our research is focused primarily in three areas:

1. Post-transcriptional regulatory mechanisms involved in axis polarization and cell fate specification during Caenorhabditis elegans embryogenesis.

2. Characterization of post-transcriptional regulatory mechanisms that guide oligodendrocyte differentiation and myelin formation in the vertebrate central nervous system.

3. Identification of small molecule inhibitors of RNA-binding protein function using high throughput screening approaches.

We employ a combination of biochemical and molecular genetic methods, bioinformatics, chemical biology, biophysics, and structural analsyses in our studies, with a focus on quantitative measurements.

Read more about our research here.

The Lazare Research Building:
Recent Publications:

Clingman CC, Deveau LM, Hay SA, Genga RM, Shandilya SM, Massi F, Ryder SP. Allosteric inhibition of a stem cell RNA-binding protein by an intermediary metabolite. Elife.2014 Jun 16:e02848. doi: 10.7554/eLife.02848. PubMed PMID: 24935936; PubMed Central PMCID: PMC4094780.

Kaymak E, Ryder SP. RNA recognition by the Caenorhabditis elegans oocyte maturation determinant OMA-1. J Biol Chem.2013 Oct 18;288(42):30463-72. doi: 10.1074/jbc.M113.496547. Epub 2013 Sep 6. PubMed PMID: 24014033; PubMed Central PMCID: PMC3798510.

Zearfoss NR, Johnson ES, Ryder SP. hnRNP A1 and secondary structure coordinate alternative splicing of Mag. RNA. 2013 Jul;19(7):948-57. doi: 10.1261/rna.036780.112. Epub 2013 May 23. PubMed PMID: 23704325; PubMed Central PMCID: PMC3683929.

Farley BM, Ryder SP. POS-1 and GLD-1 repress glp-1 translation through a conserved binding-site cluster. Mol Biol Cell. 2012 Dec;23(23):4473-83. doi: 10.1091/mbc.E12-03-0216. Epub 2012 Oct 3. PubMed PMID: 23034181; PubMed Central PMCID: PMC3510010.

Contact Information:
Sean P Ryder, Ph.D.
Associate Professor

Department of Biochemistry and Molecular Pharmacology
University of Massachusetts Medical School
364 Plantation Street, LRB-906
Worcester, MA 01605

Office Phone: 508-856-1372
Lab Phone1: 508-856-3568
Lab Phone2: 508-856-3718
General Fax: 508-856-6464
E-mail: sean.ryder_AT_umassmed.edu

Campus Address: Lazare Research Building, 9th floor, Office 906

Our laboratory is located in the Lazare Research Building of the University of Massachusetts Medical School. We enjoy a collaborative research environment that includes colleagues with related interests in worm biology, RNA biochemistry, developmental biology, or biophysics.

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Last updated: September 2014 Home Research People Publications Links

Sean P. Ryder, Ph.D.
Associate Professor
Department of Biochemistry and Molecular Pharmacology
University of Massachusetts Medical School

Joined the faculty in August of 2005.