We are interested in understanding the mechanisms that govern post-transcriptional regulation of gene expression during development and complex disease. Our research is focused primarily in three areas:
1. Post-transcriptional regulatory mechanisms involved in axis polarization and cell fate specification during Caenorhabditis elegans embryogenesis.
2. Characterization of post-transcriptional regulatory mechanisms that guide oligodendrocyte differentiation and myelin formation in the vertebrate central nervous system.
3. Identification of small molecule inhibitors of RNA-binding protein function using high throughput screening approaches.
We employ a combination of biochemical and molecular genetic methods, bioinformatics, chemical biology, biophysics, and structural analsyses in our studies, with a focus on quantitative measurements.
Read more about our research here.
Clingman CC, Deveau LM, Hay SA, Genga RM, Shandilya SM, Massi F, Ryder SP.
Allosteric inhibition of a stem cell RNA-binding protein by an intermediary
metabolite. Elife.2014 Jun 16:e02848. doi: 10.7554/eLife.02848. PubMed PMID: 24935936; PubMed Central PMCID: PMC4094780.
Kaymak E, Ryder SP. RNA recognition by the Caenorhabditis elegans oocyte maturation determinant OMA-1. J Biol Chem.2013 Oct 18;288(42):30463-72. doi: 10.1074/jbc.M113.496547. Epub 2013 Sep 6. PubMed PMID: 24014033; PubMed Central PMCID: PMC3798510.
Zearfoss NR, Johnson ES, Ryder SP. hnRNP A1 and secondary structure coordinate alternative splicing of Mag. RNA. 2013 Jul;19(7):948-57. doi: 10.1261/rna.036780.112. Epub 2013 May 23. PubMed PMID: 23704325; PubMed Central PMCID: PMC3683929.
Farley BM, Ryder SP. POS-1 and GLD-1 repress glp-1 translation through a conserved binding-site cluster. Mol Biol Cell. 2012 Dec;23(23):4473-83. doi: 10.1091/mbc.E12-03-0216. Epub 2012 Oct 3. PubMed PMID: 23034181; PubMed Central PMCID: PMC3510010.
Campus Address: Lazare Research Building, 9th floor, Office 906
Sean P. Ryder, Ph.D.
Department of Biochemistry and Molecular Pharmacology
University of Massachusetts Medical School
Joined the faculty in August of 2005.