We are interested in understanding the mechanisms that govern post-transcriptional regulation of gene expression during development and complex disease. Our research is focused primarily in three areas:
1. Post-transcriptional regulatory mechanisms involved in axis polarization and cell fate specification during Caenorhabditis elegans embryogenesis.
2. Characterization of post-transcriptional regulatory mechanisms that guide oligodendrocyte differentiation and myelin formation in the vertebrate central nervous system.
3. Identification of small molecule inhibitors of RNA-binding protein function using high throughput screening approaches.
We employ a combination of biochemical and molecular genetic methods, bioinformatics, chemical biology, biophysics, and structural analsyses in our studies, with a focus on quantitative measurements.
Read more about our research here.
Farley, B.M. and Ryder, S.P. (2012) Mol. Biol. Cell, 23, 4473-4483.
Zearfoss, N.R. and Ryder, S.P. (2012) Methods Mol Biol., 941, 181-193.
Broderick, J.A., Salomon, W., Ryder, S.P., Aronin, N., and Zamore, P.D. (2011) RNA. 17, 1858-1869.
Kalchhaueser, I., Farley, B.M., Pauli, S., Ryder, S.P., and Ciosk, R, (2011) EMBO J. 30, 3823-3829.
Wright, J.E., Gaidatzis, D., Senften, M., Farley, B.M., Westhof, E., Ryder, S.P., Ciosk, R. (2011) EMBO J. 30, 533-545.
Zearfoss, N.R., Clingman, C.C., Farley, B.M., McCoig, L.M., and Ryder, S.P. (2011) PLoS Genet, 7, e1001269. doi:10.1371/journal.pgen.1001269
Pagano, J.M. Clingman, C.C., and Ryder, S.P. (2011) RNA, 17, 14-20.
Campus Address: Lazare Research Building, 9th floor, Office 906
Sean P. Ryder, Ph.D.
Department of Biochemistry and Molecular Pharmacology
University of Massachusetts Medical School
Joined the faculty in August of 2005.