Recent Publications

Noyes, M.B., Christensen, R.G., Wakabayashi, A., Stormo, G.D., Brodsky, M.H.; Wolfe, S.A. (2008) Analysis of homeodomain specificities allows the family-wide prediction of preferred recognition sites. Cell, 133, 1277-1289. (Preview Cell, 2008, 133, 1133 & Editor’s Choice Science 2008, 321, 16.) PubMed

Meng, X., Noyes, M.B., Zhu, L.J., Lawson, N.D., Wolfe, S.A. (2008) Targeted gene inactivation in zebrafish using engineered zinc finger nucleases. Nat Biotechnol, 26, 695-701. (Research Highlight in Nature 2008, 453, 700 & Nat. Methods 2008, 5, 579.) PubMed

Noyes, M.B., Meng, X., Wakabayashi, A., Sinha, S., Brodsky, M.H.; Wolfe, S.A. (2008) A systematic characterization of factors that regulate Drosophila segmentation via a bacterial one-hybrid system. Nucleic Acids Research, 36, 2547-2560. PubMed

Meng, X., Thibodeau-Beganny, S., Jiang, T., Joung, J. K., and Wolfe, S. A. (2007) Profiling the DNA-binding specificities of engineered Cys2His2 zinc finger domains using a rapid cell-based method. Nucleic Acids Research, 35(11), e81.

Meng, X., Wolfe, S.A. (2006) Identifying DNA sequences recognized by a transcription factor using a bacterial one-hybrid system. Nature Protocols 1, 30.

Meng, X., Brodsky, M.H., and Wolfe, S.A. (2005) A bacterial one-hybrid system for determining the DNA-binding specificity of transcription factors. Nat. Biotechnol., 23: 988-994.

Wolfe, S.A., Grant, R.A., and Pabo, C.O. (2003) Structure of a designed dimeric zinc finger protein bound to DNA. Biochemistry, 42: 13401-13409.

Wolfe, S.A., Grant, R.A., Elrod-Erickson, M., and Pabo, C.O. (2001) Beyond the "recognition code": structures of two Cys2His2 zinc finger/TATA box complexes. Structure, 9: 717-723.

Wolfe, S.A, Ramm, E.I., and Pabo, C.O. (2000) Combining structure-based design with phage display to create new Cys2His2 zinc finger dimers. Structure, 8: 739-750.

Wolfe, S.A., Nekludova, L., and Pabo, C.O. (2000) DNA recognition by Cys2His2 zinc finger proteins. Ann. Rev. Biophys. Biomol. Struct., 29: 183-212.

Wolfe, S.A., Greisman, H.A., Ramm, E.I., and Pabo, C. O. (1999) Analysis of zinc fingers optimized via phage display: evaluating the utility of a recognition code. J. Mol. Biol., 285: 1917-1934.

Pomerantz, J.P., Wolfe, S.A., and Pabo, C.O. (1998) Structure-based design of a dimeric zinc finger protein. Biochemistry, 37: 965-970.

Erlanson, D.A., Wolfe, S.A., Chen, L., and Verdine, G.L. (1997) Selective base-pair destabilization enhances binding of a DNA methyltransferase. Tetrahedron, 53: 12041-12056.

Wolfe, S.A., Zhou, P., Dtsch, V., Chen, L., You, A., Ho, S.H., Crabtree, G.R., Wagner, G., and Verdine, G.L. (1997) Unusual Rel-like architecture in the DNA-binding domain of the transcription factor NFATc. Nature, 385: 172-176.

Wolfe, S.A., Ferentz, A.E., Grantcharova, V., Churchill, M.E.A.,and Verdine, G.L. (1995) Modifying the helical structure of DNA by design: recruitment of an architecture-specific protein to an enforced DNA bend. Chem. Biol., 2: 213-221.

Wolfe, S.A. and Verdine, G.L. (1993) Ratcheting torsional stress in duplex DNA. J. Am. Chem. Soc., 115: 12585-12586.

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