Our research is focused on four related areas:
- Engineering programmable nucleases for the targeted cleavage of a single site within a vertebrate genome
- We are particularly interested in engineering Cas9 systems with improved precision and targeting range
- Applying programmable nucleases to interrogate gene regulatory networks - Dendritic cell project
- Applying programmable nucleases to understand the influence of chromatin architecture on transcriptional activity - 4D Nucleome project
- Applying programmable nucleases to understand latent HIV genome structure for nuclease-based erradication- HIV project
- Understanding fundamental aspects of protein-DNA recognition - Cys2His2 zinc finger and homeodomain-DNA recognition
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Additional information on the Wolfe lab and the MCCB Department can be found here
We are interested in having rotation students in 2015 (Rotation Projects).
A Postdoctoral Fellow position is currently available (Click Employment below).