Our research is focused on utilizing artificial nucleases for efficient targeted genome editing:
- Engineering programmable nucleases for the targeted cleavage of a single site within a vertebrate genome for gene therapy applications
- Applying programmable nucleases to interrogate gene regulatory networks - Dendritic cell project
- Applying programmable nucleases to understand the influence of chromatin architecture on transcriptional activity - 4D Nucleome project
- Applying programmable nucleases to understand latent HIV genome structure for nuclease-based erradication- HIV project
This web site contains information about our current research interests as well as links to published protocols and datasets.
Questions about or problems with this website should be addressed to firstname.lastname@example.org
Additional information on the Wolfe lab and the MCCB Department can be found here